We validated this hypothesis using the first animal (mouse) model that recapitulates the two memory components, i.e. We here hypothesized that contextual amnesia and the hippocampal dysfunction believed to cause it constitute a critical factor in the etiology of PTSD-related hypermnesia and its persistence. Yet, the potential role of amnesia in PTSD 8, 9, 11, 12 has been left unexplored, as current research essentially focuses on the most obvious memory symptom: emotional hypermnesia. Decontextualized, traumatic memories would escape voluntary control as they would be automatically reactivated, potentially in whatever context, by the sole presence of salient cues more or less related to the trauma 14.
Namely, the memory deficit for peri-traumatic contextual cues would impair the capability of the subject to restrict fear to the traumatic place and cues. Nevertheless, certain clinicians suggest that this amnesia might play a role in the development and persistence of intrusive recollections of traumatic memories 4, 5, 6. This contextual amnesia, believed to result from hippocampal hypofunction induced by intense stress 7, 8, 9, 10, 11, 12, 13, is most frequently partial, and even very discreet sometimes. declarative) memories of their trauma, as certain aspects of the context are missing 1, 2, 3, 4, 5, 6. emotional hypermnesia), while having difficulties retrieving exhaustive narrative (i.e. PTSD patients experience recurrent and intrusive recollection of traumatic memories characterized by intense fear responses in ordinary, safe situations (i.e. Post-traumatic stress disorder (PTSD) is a devastating psychiatric disorder that develops after a traumatic event experienced as a threat of injury or death, with a lifetime prevalence of about 8% 1.
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